Kazuhiro Takekoshi Selected Research

Pheochromocytoma

12/2021	Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas.
5/2021	Hereditary pheochromocytoma/paraganglioma syndrome with a novel mutation in the succinate dehydrogenase subunit B gene in a Japanese family: two case reports.
12/2019	Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study.
8/2018	Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine.
3/2018	Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan.
12/2017	Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report.
4/2016	Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.
1/2016	Sporadic paraganglioma caused by de novo SDHB mutations in a 6-year-old girl.
3/2013	Endomyocardial biopsy in a patient with hemorrhagic pheochromocytoma presenting as inverted Takotsubo cardiomyopathy.
1/2013	Juvenile-onset hereditary pheochromocytoma-paraganglioma syndrome.

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Kazuhiro Takekoshi Research Topics

Disease

29	Pheochromocytoma 12/2021 - 03/2002
14	Paraganglioma (Paragangliomas) 12/2021 - 05/2008
13	Neoplasms (Cancer) 12/2021 - 01/2004
5	Inflammation (Inflammations) 09/2021 - 12/2012
5	Neoplasm Metastasis (Metastasis) 08/2018 - 05/2008
5	Insulin Resistance 12/2014 - 08/2007
4	Hypoxia (Hypoxemia) 02/2021 - 08/2002
3	Obesity 06/2021 - 04/2008
3	Hypertension (High Blood Pressure) 01/2015 - 10/2005
2	Wounds and Injuries (Trauma) 11/2022 - 06/2020
2	Muscular Atrophy (Muscle Atrophy) 11/2022 - 01/2020
2	Non-alcoholic Fatty Liver Disease 05/2021 - 01/2021
2	Body Weight (Weight, Body) 11/2020 - 12/2014
2	Atherosclerosis 01/2015 - 08/2011
2	Neuroblastoma 12/2004 - 02/2004
1	Fatigue 11/2022
1	Acute Kidney Injury (Acute Renal Failure) 01/2022
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021
1	Sarcopenia 11/2020
1	Muscle Weakness 11/2020
1	Myalgia 07/2020
1	Knee Osteoarthritis 03/2020
1	Osteoarthritis 03/2020
1	Synovitis 03/2020
1	Shock 01/2020
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 08/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 04/2016
1	Takotsubo Cardiomyopathy 03/2013
1	Fibrosis (Cirrhosis) 12/2012
1	Hypertriglyceridemia 08/2011

Drug/Important Bio-Agent (IBA)

18	CatecholaminesIBA 12/2021 - 03/2002
9	Succinate Dehydrogenase (Fumarate Reductase)IBA 05/2021 - 08/2006
7	Proteins (Proteins, Gene)FDA Link 11/2022 - 01/2004
6	Messenger RNA (mRNA)IBA 08/2009 - 02/2003
5	N- succinimidyl- 3- (4- hydroxyphenyl)propionate (HPPS)IBA 04/2016 - 05/2008
4	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 12/2021 - 02/2003
4	renalaseIBA 02/2021 - 10/2018
4	AdiponectinIBA 08/2009 - 08/2007
3	EnzymesIBA 12/2021 - 02/2003
3	Epinephrine (Adrenaline)FDA LinkGeneric 01/2020 - 02/2003
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 02/2017 - 12/2006
3	Sunitinib (Sutent)FDA Link 01/2013 - 03/2012
3	Adiponectin ReceptorsIBA 08/2009 - 08/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2006 - 08/2002
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 10/2003
2	alpha-Methyltyrosine (Metirosine)FDA Link 12/2019 - 03/2018
2	LipidsIBA 12/2014 - 08/2011
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2013 - 10/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2008 - 08/2007
2	Adrenergic Receptors (Adrenergic Receptor)IBA 08/2007 - 12/2006
2	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 12/2004 - 02/2003
2	Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA 12/2004 - 02/2003
1	UbiquitinIBA 11/2022
1	Ligases (Synthetase)IBA 11/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Xanthine DehydrogenaseIBA 01/2022
1	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 12/2021
1	AntibodiesIBA 12/2021
1	Dopamine beta-HydroxylaseIBA 12/2021
1	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2021
1	MicroRNAs (MicroRNA)IBA 09/2021
1	Amino Acids FDA Link 05/2021
1	Choline (Choline Chloride)IBA 05/2021
1	Cell-Free Nucleic AcidsIBA 01/2021
1	SaltsIBA 11/2020
1	IsoenzymesIBA 07/2020
1	salicylhydroxamic acid (SHAM)IBA 03/2020
1	Oxidoreductases (Dehydrogenase)IBA 01/2020
1	AminesIBA 01/2020
1	Glucagon (Glukagon)FDA Link 01/2020
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2018
1	Myc associated factor XIBA 12/2017
1	CreatinineIBA 02/2017
1	3-Iodobenzylguanidine (Iobenguane)IBA 02/2017
1	Small Interfering RNA (siRNA)IBA 04/2016
1	Chromogranin AIBA 01/2015
1	Peptides (Polypeptides)IBA 01/2015
1	chromogranin A (344-364)IBA 01/2015
1	Glucose (Dextrose)FDA LinkGeneric 12/2014
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2013
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2013
1	Sterol Regulatory Element Binding ProteinsIBA 12/2012
1	InflammasomesIBA 12/2012
1	PalmitatesIBA 12/2012
1	VLDL CholesterolIBA 08/2011
1	VLDL LipoproteinsIBA 08/2011
1	HDL CholesterolIBA 08/2011
1	Lipoproteins (Lipoprotein)IBA 08/2011
1	LDL Receptors (LDL Receptor)IBA 08/2011
1	SterolsIBA 08/2011
1	Triglycerides (Triacylglycerol)IBA 08/2011
1	ElementsIBA 08/2011
1	CholesterolIBA 08/2011
1	Sterol Regulatory Element Binding Protein 1IBA 08/2011

Therapy/Procedure

2	Cryotherapy (Therapy, Cold) 11/2022 - 06/2020
1	Radiotherapy 01/2021
1	Aftercare (After-Treatment) 01/2021
1	Meniscectomy 03/2020
1	Denervation 01/2020